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موضوع انگلیسی:Separating the true from the false
بخشی از متن:Cannabis is one of the oldest cultivated plant, which has been used by humankind for thousands of years due to
its biological properties and a wide range of applications. In total, hemp plants contain over 500 different
substances while the characteristic components are the cannabinoids. The most important cannabinoids are
(-)-Δ9-trans-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and cannabinol (CBN – the latter being an
oxidation product resulting from Δ9-THC). In the course of recent years, a paradigm shift has taken place with
regard to the use of products and ingredients derived from hemp, especially CBD. Thus, an ever-increasing
number of products containing CBD are on the market; this ranges from classic CBD oil to CBD chewing gum
and even CBD shampoo. Despite an increasing presence of these products in the market, the regulation of
cannabinoids in these products is very inconsistent in different countries, except for Δ9-THC whose limit is 0.2%
for many products and many countries. The enormous abundance of CBD-containing products calls for the
development of new analytical techniques that allow a reliable and quick determination of the main cannabinoids
usually found in hemp. This seems all the more necessary since previous examinations of CBD oils often
revealed a difference between the declared amount and the actual content of the ingredients. Many methods
usually applied to determine cannabinoids are rather time-consuming and associated with high costs. In this
study, we developed and validated a sensitive, simple, reliable as well as fast method for the determination of
CBN, CBD and Δ9-THC in commercially available CBD oils using high-performance thin-layer chromatography
(HPTLC) combined with electrospray ionization mass spectrometry (ESI-MS). Thus, for this method, a recovery
rate of ≥ 90% was determined. This procedure enables both qualitative and quantitative analyses of CBN, CBD
and Δ9-THC in CBD oils of different matrices such as hempseed oil, olive oil or sunflower oil. Thus, this method is
a helpful and fast tool to investigate a broad variety of commercially available CBD oils
