دانلود ترجمه مقاله فعالیت پروتئاز گردۀ آلرژی زای Cedar, Cypress, Juniper, Birch and Ragweed
ترجمه در قالب فایل Word و قابل ویرایش میباشد
سال انتشار:2008
تعداد صفحه ترجمه:14
تعداد صفحه فایل انگلیسی:9
موضوع انگلیسی :Protease Activity of Allergenic Pollen
of Cedar, Cypress, Juniper,
Birch and Ragweed
موضوع فارسی:دانلود ترجمه مقاله فعالیت پروتئاز گردۀ آلرژی زای Cedar, Cypress, Juniper, Birch and Ragweed
چکیده انگلیسی:ABSTRACT
Background: Pollen is an important trigger of allergic rhinitis, conjunctivitis, andor asthma, and an exacerbating
factor in atopic dermatitis. Although it is proposed that protease activity from allergen sources, such as
mites, enhances allergenicity, little information is available on that from relevant allergenic pollens such as
Japanese cedar and Japanese cypress pollens, which are the major cause of pollinosis in Japan.
Methods: We analyzed the protease activities derived from allergenic pollen of Japanese cedar, Japanese cypress,
and Rocky mountain juniper, which belong to the CupressaceaeTaxodiaceae family, and white birch
and short ragweed, using synthetic substrates and class-specific inhibitors.
Results: We found that the pollen of the three members of the CupressaceaeTaxodiaceae family contained
serine protease activity, that the pollen of white birch and short ragweed contained not only serine protease activity
but also cysteine protease activity, that all five types of pollen tested contained at least one other type of
serine protease, whose sensitivity to a serine protease-specific inhibitor was relatively low, and that the content
and releasability of the pollen-derived proteases differed according to the plant families.
Conclusions: Clinically relevant allergenic pollens tested in the present study can release serine andor cysteine
endopeptidases. Information on the spectrum of the endopeptidase activities from these allergenic pollen
grains will be useful for investigating their contribution to the pathogenesis of allergies.
چکیده فارسی:زمینه: گرده محرک مهم تورم غشاء مخاط بینی، ورم ملتحمه و آسم میباشد و علاوه بر این در آماس سطح پوست نیز نقش دارد. با وجود اینکه مطرح میشود که فعالیت پروتئازی ناشی از منابع آلرژی مانند ذرات ریز ،حساسیت وآلرژی زایی رابیشتر می کند، اما اطلاعات کمی در این باره از گرده های آلرژی زا مانند گردۀ cedar ژاپنی و cypress ژاپنی وجود دارد. این درخت ها عامل اصلی تب یونجه در ژاپن میباشند.
