دانلودمقاله باموضوع نتیجه دراز مدت ثانویه سندرم نفروتیک مقاوم به استروئید در کودکان چینی
در قالب pdf و در 7 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:Long-Term Outcome of Secondary
Steroid-Resistant Nephrotic Syndrome
in Chinese Children
بخشی از متن:Introduction: Secondary steroid-resistant nephrotic syndrome (SRNS) refers to the condition when patients
with initial steroid-sensitive nephrotic syndrome develop steroid resistance in subsequent relapses.
Long-term outcomes of secondary SRNS in children are uncertain.
Methods: This was a single-center retrospective study of 56 children with secondary SRNS between 2006
and 2016. The survival curve was estimated using the Kaplan-Meier method. Independent risk factors for
end-stage renal disease (ESRD) were determined using Cox proportional hazards model.
Results: The median time from nephrotic syndrome onset to secondary SRNS was 7.8 months. Biopsy
results at diagnosis secondary SRNS showed that 64.3% of cases were minimal change disease (MCD). No
remission was observed in seven (12.5%) patients within the first year. The mean follow-up time was 7.8
3.2 years. Eight patients were clinically cured, one died before ESRD, 10 reached ESRD, and 75.0% (3 of 4)
of patients recurred post-transplantation. The 10-year ESRD-free survival rate was 85.8%. No response to
intensified immunosuppression (IIS) in the first year was the independent predictor for ESRD. Repeat
biopsies were performed in 20 cases, revealing that the reclassification from MCD to mesangial hypercellularity
and focal segmental glomerulosclerosis (FSGS) in two when secondary steroid resistance
appeared, from MCD and mesangial hypercellularity to FSGS in seven who developed multidrug resistance,
and from FSGS to MCD and mesangial hypercellularity in two with favorable outcomes.
Conclusions: The long-term outcome in children with secondary SRNS was heterogeneous, and no
response to IIS in the first year was the independent predictor for ESRD. In patients with repeat biopsy,
changes in histological appearance to FSGS were associated with multidrug resistance.
