دانلود مقاله با موضوع فعالیت آنتی اکسیدانی، ضد باکتریایی و الکتروشیمیایی لیگاند
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موضوع به انگلیسی:Antioxidant, antibacterial and electrochemical activity of
(E)-N-(4 (dimethylamino) benzylidene)-4H-1,2,4-triazol-4-amine ligand
and its transition metal complexes
بخشی از متن:Transition metal complexes of Ni(II) (1), Co(II) (2) and Cu(II) (3) supported by a Schiff base ligand, namely (E)‐
N‐(4 (dimethylamino)benzylidene)‐4H‐1,2,4‐triazol‐4‐amine (L) have been synthesized. The ligand has been
characterized by various spectral studies (1H NMR, 13C NMR, FTIR, UV–Vis and ESI‐MS). The metal complexes
have been characterized by FTIR, UV–Vis, ESI‐MS and elemental analysis. . Elemental analysis and ESI‐MS studies
confirmed that metal complexes form at 1:2 (metal:ligand) ratio. The electrochemical behaviors of the
metal complexes in acetonitrile have also been studied using cyclic voltammetry and metal complexes have
showed by reducing in their metal center. In vitro stable free radical 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH)
scavenging assay was used to estimate the antioxidant activity of ligands and its metal complexes. Complex
3 exhibited most potent scavenging property with IC50 value 1.97 ± 0.08 μg/mL among the tested compounds
compared to the standard antioxidant ascorbic acid (IC50 value 1.14 ± 0.17 μg/mL). Antibacterial screening
investigated by disc diffusion method against gram positive (Staphylococcus aureus, Bacillus subtilis and
Staphylococcus epidermidis) and gram negative (Escherichia coli) bacterial strains. The result has exhibited that
the complex 2 had prominent inhibitory property against gram positive bacterial strains at the dose of 250 μg/
mL and 500 μg/mL. Moreover, the complex 3 have also showed good antibacterial activity against
Staphylococcus aureus and Bacillus subtilis at the dose of 500 μg/mL
