دانلود مقاله با موضوع بیفلاوونوئید به عنوان مهارکننده بالقوه پروتئاز 3-کیموتریپسین مانند (3CLpro)
در قالب pdf و در 14 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of
SARS-Coronavirus
بخشی از متن:3CL protease is one of the key proteins expressed by SARS‐Coronavirus‐2 cell, the potential to be targeted in the
discovery of antivirus during this COVID‐19 pandemic. This protein regulates the proteolysis of viral polypeptide
essential in forming RNA virus. 3CL protease (3CLpro) was commonly targeted in the previous SARSCoronavirus
including bat and MERS, hence, by blocking this protein activity, the coronavirus should be eradicated.
This study aims to review the potency of biflavonoid as the SARS‐Coronavirus‐2 3CLpro inhibitor. The
review was initiated by describing the chemical structure of biflavonoid and followed by listing its natural
source. Instead, the synthetic pathway of biflavonoid was also elaborated. The 3CLpro structure and its function
were also illustrated followed by the list of its 3D‐crystal structure available in a protein data bank. Lastly,
the pharmacophores of biflavonoid have been identified as a protease inhibitor, was also discussed. This review
hopefully will help researchers to obtain packed information about biflavonoid which could lead to the study in
designing and discovering a novel SARS‐Coronavirus‐2 drug by targetting the 3CLpro enzyme
