دانلود مقاله با موضوع خصوصیات یک آریل پیپرازین/2-هیدروکسی پروپیل-β-سیکلودکسترین ارتباط
در قالب pdf و در8 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:Characterization of an aryl piperazine/2-hydroxypropyl-β-cyclodextrin
association, a complex with antidiabetic potential
بخشی از متن:This study explores the molecular association between 4-(thiophen-2-yl)-1-(4-(4-(trifluoromethyl)phenyl)
piperazin-1-yl)butan-1-one (RTC1), an antidiabetic compound recently reported by our research group with
challenging aqueous solubility, and 2-hydroxypropyl-β-cyclodextrin (HPBCD). The formation of a RTC1/HPBCD
complex resulted in improved solubility. A phase-solubility diagramwas used to determine the complex stability
constant and stoichiometric ratio. 2D 1H NMR spectroscopy was utilized to study the molecular interaction between
RTC1 and HPBCD in the complex. Differential scanning calorimetry and scanning electron microscopy
was also employed to confirm complex formation. In vitro biological evaluation, using a glucose uptake assay,
showed that the homogeneous RTC1/HPBCD complex solution showed the same activity to that of RTC1 alone,
with no reduction in activity due to the presence of HPBCD.
