دانلود مقاله با موضوع روش جدید برای سنتز سولفونامید اوره از p-toluene سولفونیل ایزوسیانات
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موضوع به انگلیسی:Novel method for the synthesis of Sulfonamide Urea’s from p-toluene
sulfonyl isocyanate using Amberlite IRA-400 Cl resin: Application towards
the synthesis of Gliclazide
بخشی از متن:Novel and facile method for the synthesis of sulfonyl urea’s from p-toluene sulfonyl isocyanates with different
amines using Amberlite IRA-400 Cl resin in NMP was reported. Different aromatic, aliphatic and heterocyclic
amines were used to test the reaction conditions and most of the amines were well tolerated to form their
corresponding sulfonyl urea’s in good to better yields. Using this methodology Gliclazide, an anti-diabetic drug
was synthesized in 88% yield. Simple operational procedure, less reaction time, no chromatographic purification
makes this methodology simple and practical
