دانلود مقاله با موضوع مطالعات طیف سنجی، ضد سرطانی و آنتی اکسیدانی فلاکسیونال کمپلکس های ترانس
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موضوع به انگلیسی:Spectroscopic, anticancer and antioxidant studies of fluxional
trans-[PdCl2(S-acylthiourea)2] complexes
بخشی از متن:A library of palladium(II) acylthiourea complexes (1–6) of the type [PdCl2{C8H13N2OS(R)}2] [where R =
C6H4CH3(o) (1), C6H5 (2), C6H4OCH3(p) (3), C6H4OC2H5(p) (4), C10H7 (5) or C6H5Cl(p) (6)] was synthesized and
characterized by UV–Visible, FT-IR, 1H NMR, 13C NMR and ESI-Mass spectroscopy, and elemental analysis.
Single crystal X-ray structure of complex 4 revealed the monodentate coordination of acylthiourea ligand
through sulphur atom to the palladium ion in a trans fashion. In addition, variable-temperature (VT) NMR studies
were performed to analyze the fluxional nature of complexes. The interaction of complexes with calf thymus (CT)
DNA and BSA (bovine serum albumin) was analyzed by spectroscopic and molecular docking studies. The results
inferred intercalation binding mode of the complexes with DNA. All the complexes exhibited good binding with
BSA as well. Further, the complexes were found to act as good scavengers of DPPH as deduced from the antioxidant
assay. In vitro cytotoxicity of the compounds against A549 (lung) cancer and HEK293 (human embryonic
kidney) normal cell lines was investigated by MTT assay. Among the six complexes, complex 5 bearing a napthyl
substitution in acylthiourea exhibited a remarkable activity against A549 cell line with an IC50 value of 14.8 μM
and was more active than cisplatin (IC50 = 17.8 μM). On the other hand, it showed less toxicity on HEK293 cell
line. The cell death mechanism was analyzed by AO/EB and DAPI staining, flow cytometry and Western blot
investigations, which revealed that complex 5 could initiate cell death through apoptosis.
