دانلود مقاله با موضوع سنتز مشتقات جدید کومارین-تیازولیدین-2،4-دیون: یک رویکرد به مطالعات محاسباتی
در قالب pdf و در 8 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:Synthesis of novel coumarin-thiazolidine-2,4-dione derivatives: An approach
to computational studies and biological evaluation
بخشی از متن:A series of novel coumarin‐thiazolidinone hybrids 3(a‐h) have been synthesized and the obtained compounds
were analyzed by spectroscopic methods. New ccompounds were carried out for their in‐vitro antibacterial and
antifungal activities and have shown potential results. The compound (3b) has shown excellent antibacterial
activity with MIC of 0.5 μg/mL against Staphylococcus aureus, Bacillus subtilis and 1 μg/mL for Escherichia coli
and Pseudomonas aeruginosas. The compound (3d) was exhibited antifungal activity with MIC of 1 μg/mL
against Aspergillus flavus, Trichoderma harzianum, Penicillium chrysogenum and yeast Candida albicans. Further,
molecular docking investigation has been achieved against 1AD4 enzyme of antibacterial activity showed
excellent binding interactions and is in agreement with the in vitro results
