دانلود مقاله با موضوع فیبران مشتق کاهش یافته فنوفیبرات است
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موضوع به انگلیسی:Fibrane the reduced derivative of fenofibrate
بخشی از متن:Catalytic activities of Aldo-Keto reductase (AKR) protein family
members, AKR1B10 and Aldose Reductase are decreased by the fibrate
class of compounds [1–3]. Among all the first generation fibrates,
Fenofibrate is most potent inhibitor against the enzyme activities of
AKR family of proteins [1–3]. However, fibrates were previously believed
to act as agonists for the nuclear receptor, peroxisome
proliferator-activated receptor α (PPARα) and were consequently
used clinically as therapeutic agents in the treatment of hyperlipidemia,
heart disease and diabetic complications [4–8]. The ability of fibrate to
target both AKR and PPARαfamily of proteins necessitate a need to generate
a specific derivative of it that can selectively target only AKR family
rather than nuclear receptor to avoid complications and hence reduce
the side-effects or show cross interaction with molecules that leads to
undesired health consequences. Absence of an electronegative atom,
Oxygen, will alter the physical and chemical properties of fibrate derivative
under physiological condition. Lack of this heteroatom is very critical
because AKR family of proteins and nuclear receptors are two
distinct classes of protein families with different cellular role and function.
We describe herein a method for the preparation of chemically
modified derivative of the pro-drug, Fenofibrate from itself in a single
step and characterization of the derivative by spectroscopy techniques
