دانلود مقاله با موضوع سنتز، خصوصیات و فعالیت ضد باکتریایی متالوپورفیرین ها
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موضوع انگلیسی:Synthesis, characterization and antibacterial activity of
metalloporphyrins
بخشی از متن:Modification of synthetic porphyrins is one of the promising strategies in an attempt to get molecules with desired
properties and applications. Here in we report synthesis, photophysical characterization and antibacterial
activity of 5, 10, 15, 20-tetrakis-(4- methoxy carbonyl phenyl) porphyrin M(II); where M = Co, Fe, Ni, Zn.
Metallation of the ligand was confirmed by using UV–Vis spectroscopy and ESI-Ms measurement, in which the
number of Q bands in absorption spectra of the ligand decreased from four to one or two as a result of metal insertion
to the porphyrin core. The antibacterial activity study of the complexes toward two Gram-positive
(Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (s. pyogenes)) and two Gram-negative
(Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae)) bacteria by disc diffusion method showed
a promising inhibitory activity. The complexes exhibited highest activities at highest concentration and are better
than the activity of free base ligand, the salts and blank solution. This could be explained on the basis of Overton's
concept of cell permeability and Tweed's Chelation theory. An increased lipo-solubility enhances the penetration
of the complexes in to the lipid membrane and interferes in the normal activities of the bacteria. Our study, therefore,
showed that the growth inhibitory effect of thesemetalloporphyrins is generally in order of ZnTPPCOOMe>
NiTPPCOOMe > CoTPPCOOMe> FeTPPCOOMe,which may be attributed to the better lipophilicity and binding of
the complex with the cellular components
