دانلود ترجمه مقاله درمان ویتیلیگو با پهن باند فرابنفش بی و ویتامین ها
ترجمه در قالب فایل Word و قابل ویرایش میباشد
سال انتشار:2012
تعداد صفحه ترجمه:8
تعداد صفحه فایل انگلیسی:3
موضوع انگلیسی :PTDHroenAa tRemtM eanlA.t CofO vLitOiliGgoY and THERAPEUTICS
Treatment of vitiligo with broadband ultraviolet B and vitamins
موضوع فارسی:دانلود ترجمه مقاله درمان ویتیلیگو با پهن باند فرابنفش بی و ویتامین ها
چکیده انگلیسی:Abstract
Background
While oral psoralen plus ultraviolet A (PUVA) remains the most popular
therapeutic modality for vitiligo, recent reports have shown that narrowband ultraviolet B (UVB)
also induces significant repigmentation. In this study we evaluated the efficacy of broadband
UVB on actively spreading, progressive vitiligo in patients who had been followed for many
months (12 or more) in our practice, who continued to depigment despite treatment.
Methods
Nine patients with actively spreading vitiligo were exposed to broadband UVB 2–3
times per week at a starting dose of 20–30 mJ/cm
2
. Radiation was increased by 10–20 mJ/cm
2
per session with adjustments for symptomatic erythema or missed visits. In addition, patients
took vitamin C 500 mg twice a day (BID), vitamin B
12
1000
μ
g BID and folic acid 5 mg BID. The
response to treatment and side-effects were assessed at each visit. The patient’s response to
treatment and progress were assessed by photographs and by physician evaluation of body
surface area (BSA) (using the Rule of 9s) involved at monthly intervals. Photographs were taken
and estimations of BSA by physical examination made at the start and finish of the trial and then
compared by the physicians involved in the study.
Results
Broadband UVB halted the progression of vitiligo in all nine patients and in general
induced repigmentation early after 8–12 treatments (6–8 weeks). After 2–8 months of
treatment, nine of nine patients achieved good (51–75%) or excellent response (76–100%). The
percentage of repigmentation varied with length of treatment and anatomic site.
Conclusions
This study confirms the only published report that broadband UVB is effective
on actively spreading vitiligo. Since it is more cost effective than narrowband UVB and has
numerous advantages compared to oral PUVA, broadband UVB may offer an alternative for
future treatment of vitiligo. The role of vitamins in this therapy remains to be determined
چکیده فارسی:پیشینه؛ در حالی که psoralen plus ultraviolet A (PUVA) خوراکی همچنان فراگیرترین مدالایتۀ درمانی ویتیلیگو است، گزارشات اخیر نشان داده است که ultraviolet B (UVB) باندباریک، رپیگمنتاسیون معنی دار را نیز تحریک می کند. ما در این مطالعه اثربخشی UVB باندپهن بر ویتیلیگوی پیش رونده و فعال را در بیمارانی که طی چند ماه (12 ماه یا بیشتر) در مطب پیگیری شده بودند ارزیابی کردیم. این بیماران باوجود درمان، همچنان با دپیگمنت مواجه بودند.
