دانلود مقاله با موضوع پتانسیل ضد سرطانی 3-هیدروکسی پیریدین-2-کربوکسالدئید N(4)-متیل
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موضوع به انگلیسی:Anticancer potential of 3-hydroxypyridine-2-carboxaldehyde N(4)-methyl
and pyrrolidinylthiosemicarbazones and their Zn(II) complexes
بخشی از متن:
Zinc(II) complexes of 3‐hydroxy‐2‐formylpyridine N(4)‐methylthiosemicarbazone (1) and 3‐hydroxy‐2‐
formylpyridine N(4)‐pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized and characterized
by elemental analysis, IR, UV–Vis, 1H NMR spectroscopy and mass spectrometry. These compounds were investigated
for their antiproliferative potential against PC3 (Prostate Cancer), DU145 (Prostate Cancer), A549
(Lung Cancer), A431 (skin cancer) and Hela (Cervical Cancer cell) cell lines. All the compounds showed good
antiproliferative activity against the tested cell lines. However, compound HHyPyPyrd showed remarkable
antiproliferative activity against PC3 cell line with an IC50 of 0.69 μM. Cell death analysis by propidium iodide
staining showed significant increase in cell death of PC3 cells in a concentration dependent manner.
Furthermore, cell cycle analysis showed cell cycle arrest of PC3 cells at S phase. Our study shows that compound
HHyPyPyrd induces the downregulation of JNK, c‐Jun and Erk.
