دانلود مقاله با موضوع طراحی و سنتز آنتاگونیست های جدید گیرنده استروژن با استال حاوی اسکلت بی فنیل متان
در قالب pdf و در 6 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:Design and synthesis of novel estrogen receptor antagonists with acetal
containing biphenylmethane skeleton
بخشی از متن:Novel compounds bearing acetal groups in their biphenylmethane skeletons were synthesized in moderate
yields from benzophenone derivative. Compound 1 did not exhibit antagonistic activity against the ERα estrogen
receptor; however, compounds 2, 3, and 4 exhibited potent ERα antagonistic activities. A small difference
in the ERα antagonistic activities of the stereoisomers was observed. It was suggested that the methyl groups on
the acetal moieties were responsible for the observed ERα antagonistic activities of the compounds. These
results could be attributed to interactions of the methyl groups of the acetal functional groups with the
hydrophobic binding residues of the binding site.
