دانلود مقاله با موضوع اساس مولکولی کورستین به عنوان مخرج مشترک قابل قبول COVID-19
در قالب pdf و در 4 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:Molecular basis of quercetin as a plausible common denominator of
macrophage-cholesterol-fenofibrate dependent potential COVID-19
treatment axis
بخشی از متن:The world’s largest randomized control trial against COVID-19 using remdesivir, hydroxychloroquine, lopinavir
and interferon-β1a appeared to have little or no effect on hospitalized COVID-19 patients. This has again led to
search for alternate re-purposed drugs and/or effective “add-on” nutritional supplementation, which can complement
or enhance the therapeutic effect of re-purposed drug. Focus has been shifted to therapeutic targets of
severe acute respiratory syndrome coronavirus (SARS-CoV-2), which includes specific enzymes and regulators of
lipid metabolism. Very recently, fenofibrate (cholesterol-lowering drug), suppressed the SARS-CoV-2 replication
and pathogenesis by affecting the pathways of lipid metabolism in lung cells of COVID-19 patients. A preclinical
study has shown synergistic effect of quercetin (a flavonoid) and fenofibrate in reducing the cholesterol content,
which might be useful in COVID-19 treatment. Based on the scientific literature, use of quercetin and fenofibrate
in COVID-19 seems meaningful in pharmaceutical and biomedical research, and warrants basic, experimental
and clinical studies. In this article, we have summarized the contemporary findings about drug fenofibrate and its
effect on membrane synthesis of COVID-19 virus along with emphasizing on possible synergistic effects of
quercetin with fenofibrate
