دانلود مقاله با موضوع کاردنولید گلیکوزید جدید مضعف CNS از ریشه خرزهره نریم
در قالب pdf و در 5 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:New CNS depressant cardenolide glycoside from the roots of
Nerium oleander
بخشی از متن:A newcentral nervous system(CNS) depressant cardenolide glycoside named nerioleanderoside (1)was isolated
fromactive n-butanol fraction of the aqueous- ethanolic (5:95 v/v) extract of the fresh dried roots of Nerium oleander.
The chemical structure of nerioleanderoside was elucidated as 3β-O-(D-diginosyl)-15 β-O-(Dglucopyranosyl)-
14 β -hydroxy-card-20(22)-enolide, through spectroscopic methods including IR, HRMS,
NMR spectroscopy and acidic hydrolysis. One more new cardinolide glycoside (2), fully characterized
stereochemically as 3 β-O-(D-diginosyl)-(1 → 4) β-(D-glucopyranosyl)-14 β-hydroxy-card-20(22)-enolide was
isolated from same n-butanol fraction. The pure nerioleanderoside (1) exhibited CNS depressant activity in
Swiss mice at the dose of 15 mg/kg.
