دانلود مقاله با موضوع تجزیه و تحلیل همزمان استون، متیل اتیل کتون (MEK) و متیل ایزوبوتیل کتون (MIBK)
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موضوع به انگلیسی:Simultaneous analysis of acetone, methyl ethyl ketone (MEK), and methyl
isobutyl ketone (MIBK) in urine by headspace gas chromatography-flame
ionisation detection (HS GC-FID)
بخشی از متن:Acetone, methyl ethyl ketone (MEK), and methyl isobutyl ketone (MIBK) are ketones most widely used in
industry and whose analysis is often used for the determination of occupational exposure. Current literature
represents expensive and timeous methods to detect these three ketones simultaneously. This research aims
to present a simple, rapid, current, inexpensive, and validated method, for routine analysis and simultaneous
detection of acetone, MEK, and MIBK in urine, using headspace gas chromatography with a flame ionisation
detector (HS GC‐FID), with no prior sample treatment. A general “dilute and shoot” method was used and validated
for the following: selectivity, linearity, accuracy and precision, matrix effects, reproducibility, repeatability,
ruggedness, carryover, and uncertainty of measurement. The calibration standards showed linearity for
all compounds in the working analytical range of 0.80 mg/L to 100 mg/L and correlation coefficient values
of > 0.99. The method was selective and produced an LOD of 0.01 mg/L and LOQ of 0.03 mg/L. This method
passed all method validation parameters. Each run was completed in less than five minutes. In conclusion, this
method is fast, reliable, and requires no sample pre‐treatment. The combined uncertainty of measurement was
less than 15% for all three ketones and should be taken into consideration when reporting results. The method
was therefore deemed fit for routine analysis for the simultaneous detection of acetone, MEK, and MIBK in
urine
