دانلود مقاله با موضوع سنتز، خصوصیات، ارزیابی ضد التهابی، مولکولی مطالعات تئوری تابعی اتصال
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موضوع به انگلیسی:Synthesis, characterization, anti-inflammatory evaluation, molecular
docking and density functional theory studies of metal based drug candidate
molecules of tenoxicam
بخشی از متن:Nonsteroidal anti‐inflammatory drugs (NSAIDs) are one of the most important therapeutic agents used for the
treatment of a variety of inflammation. Tenoxicam (TNX), which is used to relieve inflammation, swelling, and
pain associated with rheumatoid arthritis, is a member of NSAIDs. In this study, copper(II), zinc(II), platinum
(II) and palladium(II) complexes of TNX were synthesized and characterized by analytical and instrumental
techniques (Ultraviolet and visible absorption spectra (UV–Vis), Liquid chromatography–mass spectrometry
(LC‐MS), Inductively coupled plasma ‐ optical emission spectrometry (ICP‐OES), Differential thermal
analysis‐Thermogravimetric analysis (DTA‐TG)). Fourier‐transform infrared (FT‐IR) spectra of the complexes
were measured and the outcome were supported by density functional theory computations. The proposed
structure of these metal complexes are [Cu(TNX)2], [Zn(TNX)2], [Pt(TNX)2] and [Pd(TNX)Cl2]. The antiinflammatory
activities of the synthesized complexes, compared with the drug, were demonstrated for the first
time. All metal complexes of the TNX acted more efficiently on the reduction of pro‐inflammatory tumor necrosis
factor (TNF)‐alpha production than that of TNX. The highest anti‐inflammatory potential was detected with
[Cu(TNX)2]. The receptor‐ligand interactions between TNX complexes and TNF‐α were revealed by molecular
docking calculations
