دانلود مقاله سنتز، فعالیت سیتوتوکسیک، ضد سرطانی و ضد میکروبی برخی از فلزات کمپلکس های یک لیگاند
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موضوع به انگلیسی:Synthesis, cytotoxic, anticancer and antimicrobial activities of some metal
complexes of a novel tetradentate Schiff base ligand, (E)-3-((2-((E)-(1-(2-
hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-phenylbutanamide
بخشی از متن:A novel tetradentate Schiff base ligand, (E)‐3‐((2‐((E)‐(1‐(2‐hydroxyphenyl)ethylidene)amino)ethyl)imino)‐Nphenylbutanamide
(HEAc) and its VO(IV), Cr(III), Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) complexes have been
synthesized. Ligand, HEAc was characterized analytically and spectroscopically. Physico‐chemical methods
like elemental analysis, molar conductance, magnetic susceptibility measurement and IR‐ and UV–vis spectral
measurements were employed for the characterization of the complexes. The cytotoxic activities of ligand and
its Cr(III), Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) complexes have been evaluated. In‐vitro cytotoxicity studies
on ligand and its metal complexes showed potential cytotoxicity against Dalton’s Lymphoma Ascites (DLA) cell
lines. Antitumour activities of this Cu(II) complex was studied using Daltons Lymphoma Ascites cell‐induced
solid tumour model and Ehrlich's Ascites Carcinoma cell‐induced ascites tumour model. Treatment with the
Cu(II) complex at three different concentrations (15, 10 and 5 mg/kg body weight) subdued the solid tumour
growth in experimental mice and increased the mean survival rate and the life span of Ascites tumour bearing
mice in a concentration dependent manner. The copper complex showed highest antitumor activity and cytotoxicity
with an IC50 value of 47 μg/ml. It was observed that all the metal complexes were more potent bactericides
and fungicides than the free ligand, HEAc and copper complex showed high antimicrobial activity than
the others
