دانلود مقاله با موضوع اسیدهای صفراوی و جراحی متابولیک
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موضوع به انگلیسی:Bile acids and metabolic surgery
بخشی از متن:The epidemic of obesity and its co-mortalities has reached an alarming level worldwide. Currently,
metabolic surgeries, especially the Roux-en-Y gastric bypass and vertical sleeve gastrectomy, are the
most effective and sustainable treatments for obesity, type 2 diabetes, non-alcoholic steatohepatitis, as
well as other metabolic diseases. However, the invasive nature of the surgeries limits their broad applications
to the general public. Therefore, developing alternative non-invasive approaches to mimic
metabolic surgery is an important direction of the field. Recent studies have identified several potential
metabolic surgery-induced downstream endocrine mediators, among which bile acids are key candidate
signaling molecules. Bile acids are profoundly altered by metabolic surgery, which contributes to the
metabolic effects of the surgery. In this review, we focus on the most recent studies on the roles of bile
acids and bile acid receptors farnesoid X receptor and Takeda G protein-coupled receptor 5 in mediating
the metabolic effects of metabolic surgery. We conclude that targeting bile acid pathways may be a
promising pharmacological approach to mimic the beneficial effects of metabolic surgery.
